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Risk Factors — Estrogen

Bone Density
Bone contains estrogen receptors and is therefore sensitive to estrogen. Estrogen inhibits bone resorption (the process of breaking down bone and "resorbing" it into the body). It also increases the production of other hormones that promote an increase in bone density.

Studies have shown that high bone density indicates a high exposure to estrogen in post-menopausal women, and perhaps longer exposure over a lifetime. Research indicates that there may be a relationship between high bone density and breast cancer risk, although hormones other than estrogen may be involved. ref